Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis
نویسندگان
چکیده
منابع مشابه
Anthracyclines induce DNA damage response-mediated protection against severe sepsis.
Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activati...
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Doxorubicin is a widely used chemotherapeutic drug that intercalates between DNA base-pairs and poisons Topoisomerase II, although the mechanistic basis for cell killing remains speculative. Doxorubicin and related anthracycline compounds have been shown to increase nucleosome turnover and/or eviction around promoters, which suggests that the resulting enhanced exposure of DNA might underlie ce...
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ژورنال
عنوان ژورنال: Immunity
سال: 2013
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2013.08.039